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1

Pyrroloquinoline Quinone, a Redox-active o -Quinone, Stimulates Mitochondrial Biogenesis by Activating SIRT1/PGC-1α Signaling Pathway

Saihara, Kazuhiro, Kamikubo, Ryosuke, Ikemoto, Kazuto, Uchida, Koji, Akagawa, Mitsugu

Journal:

Year:

2017

Language:

english

File:

PDF, 1.29 MB

english, 2017

2

Characterization of E- and Z-ajoene obtained from different varieties of garlics

Most Tahera Naznin, Mitsugu Akagawa, Kayo Okukawa, Tomoko Maeda, Naofumi Morita

Journal:

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

3

Recent progress in studies on the health benefits of pyrroloquinoline quinone

Akagawa, Mitsugu, Nakano, Masahiko, Ikemoto, Kazuto

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2015

Language:

english

File:

PDF, 421 KB

english, 2015

4

Propionate suppresses hepatic gluconeogenesis via GPR43/AMPK signaling pathway

Yoshida, Hiroki, Ishii, Megumi, Akagawa, Mitsugu

Journal:

Archives of Biochemistry and Biophysics

Year:

2019

Language:

english

File:

PDF, 3.83 MB

english, 2019

5

Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin

Takeshi Ishii, Taiki Mori, Tatsuya Ichikawa, Maiko Kaku, Koji Kusaka, Yoshinori Uekusa, Mitsugu Akagawa, Yoshiyuki Aihara, Takumi Furuta, Toshiyuki Wakimoto, Toshiyuki Kan, Tsutomu Nakayama

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 576 KB

english, 2010

6

Oxidative deamination of lysine residue in plasma protein of diabetic rats : Novel mechanism via the Maillard reaction

Mitsugu Akagawa, Takeshi Sasaki, Kyozo Suyama

Journal:

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

7

Amine oxidase-like activity of polyphenols : Mechanism and properties

Mitsugu Akagawa, Kyozo Suyama

Journal:

Year:

2001

Language:

english

File:

PDF, 984 KB

english, 2001

8

Oxidative deamination of benzylamine by glycoxidation

Mitsugu Akagawa, Takeshi Sasaki, Kyozo Suyama

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 210 KB

english, 2003

9

Formation of α-Aminoadipic and γ-Glutamic Semialdehydes in Proteins by the Maillard Reaction

MITSUGU AKAGAWA, DAISUKE SASAKI, YAYOI KUROTA, KYOZO SUYAMA

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 1.68 MB

english, 2005

10

Neurotoxic Tetrahydroisoquinoline Derivatives Formed by the Maillard Reaction between Glucose and Dopamine

KYOZO SUYAMA, YOSHIHISA ISHII, MITSUGU AKAGAWA

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 30 KB

english, 2005

11

Covalent modification of proteins by green tea polyphenol (–)-epigallocatechin-3-gallate through autoxidation

Takeshi Ishii, Taiki Mori, Tomoko Tanaka, Daisuke Mizuno, Ryoichi Yamaji, Shigenori Kumazawa, Tsutomu Nakayama, Mitsugu Akagawa

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 705 KB

english, 2008

12

Fluorescent detection of α-aminoadipic and γ-glutamic semialdehydes in oxidized proteins

Mitsugu Akagawa, Kyozo Suyama, Koji Uchida

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 617 KB

english, 2009

13

N-Formylethylation in Oxidized LDL

Chika Wakita, Kazuya Honda, Takahiro Shibata, Mitsugu Akagawa, Hitoshi Mori, Koji Uchida

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 177 KB

english, 2010

14

(−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68

Tomoko Tanaka, Takeshi Ishii, Daisuke Mizuno, Taiki Mori, Ryoichi Yamaji, Yoshimasa Nakamura, Shigenori Kumazawa, Tsutomu Nakayama, Mitsugu Akagawa

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

15

A method for detection of 4-hydroxy-2-nonenal adducts in proteins

Chika Wakita, Kazuya Honda, Takahiro Shibata, Mitsugu Akagawa, Koji Uchida

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 373 KB

english, 2011

16

Lysyl oxidase coupled with catalase in egg shell membrane

Mitsugu Akagawa, Yukie Wako, Kyozo Suyama

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 235 KB

english, 1999

17

Cyclopentenosine, Major Trifunctional Crosslinking Amino Acid Isolated from Acid Hydrolysate of Elastin

Mitsugu Akagawa, Kazuyuki Yamazaki, Kyozo Suyama

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

18

Characterization of a Model Compound for the Lysine Tyrosylquinone Cofactor of Lysyl Oxidase

Mitsugu Akagawa, Kyozo Suyama

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

19

Prion inactivation by the Maillard reaction

Kyozo Suyama, Miyako Yoshioka, Mitsugu Akagawa, Yuichi Murayama, Hiroko Horii, Masuhiro Takata, Takashi Yokoyama, Shirou Mohri

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

20

Factors influencing the early stage of the Maillard reaction

Mitsugu Akagawa, Takashi Miura, Kyozo Suyama

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 34 KB

english, 2002

21

Oxidative deamination of lysine residue in plasma protein from diabetic rat: α-dicarbonyl-mediated mechanism

Kyozo Suyama, Mitsugu Akagawa, Takeshi Sasaki

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 79 KB

english, 2002

22

Proteomic Analysis of Wheat Flour Allergens

Akagawa, Mitsugu, Handoyo, Tri, Ishii, Takeshi, Kumazawa, Shigenori, Morita, Naofumi, Suyama, Kyozo

Journal:

Journal of Agricultural and Food Chemistry

Year:

2007

Language:

english

File:

PDF, 272 KB

english, 2007

23

Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling

Kazuki Kimura, Mayumi Takada, Takeshi Ishii, Kentaro Tsuji-Naito, Mitsugu Akagawa

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

24

Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Ay mice

Mayumi Takada, Mika Sumi, Ayumi Maeda, Fumiko Watanabe, Toshikazu Kamiya, Takeshi Ishii, Masahiko Nakano, Mitsugu Akagawa

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 642 KB

english, 2012

25

Hypoallergenic Characteristics of Wheat Flour Produced by Stepwise Polishing

Handoyo, Tri, Akagawa, Mitsugu, Morita, Naofumi, Maeda, Tomoko, Mitsunaga, Toshio

Journal:

International Journal of Food Properties

Year:

2008

Language:

english

File:

PDF, 225 KB

english, 2008

26

Catechol Type Polyphenol Is a Potential Modifier of Protein Sulfhydryls: Development and Application of a New Probe for Understanding the Dietary Polyphenol Actions

Ishii, Takeshi, Ishikawa, Miki, Miyoshi, Noriyuki, Yasunaga, Mayuko, Akagawa, Mitsugu, Uchida, Koji, Nakamura, Yoshimasa

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 1.51 MB

english, 2009

27

New Method for the Quantitative Determination of Major Protein Carbonyls, α-Aminoadipic and γ-Glutamic Semialdehydes: Investigation of the Formation Mechanism and Chemical Nature in Vitro and in Vivo

Akagawa, Mitsugu, Sasaki, Daisuke, Ishii, Yoshihisa, Kurota, Yayoi, Yotsu-Yamashita, Mari, Uchida, Koji, Suyama, Kyozo

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

28

Cinnamon Extract Promotes Type I Collagen Biosynthesis via Activation of IGF-I Signaling in Human Dermal Fibroblasts

Takasao, Naoko, Tsuji-Naito, Kentaro, Ishikura, Seiko, Tamura, Azusa, Akagawa, Mitsugu

Journal:

Journal of Agricultural and Food Chemistry

Year:

2012

Language:

english

File:

PDF, 3.83 MB

english, 2012

29

Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK- A y mice

Maeda, Ayumi, Kai, Kenji, Ishii, Megumi, Ishii, Takeshi, Akagawa, Mitsugu

Journal:

Molecular Nutrition & Food Research

Year:

2014

Language:

english

File:

PDF, 529 KB

english, 2014

30

Production of Hydrogen Peroxide by Polyphenols and Polyphenol-rich Beverages under Quasi -physiological Conditions

AKAGAWA, Mitsugu, SHIGEMITSU, Tomoko, SUYAMA, Kyozo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2003

Language:

english

File:

PDF, 465 KB

english, 2003

31

Human Serum Albumin as an Antioxidant in the Oxidation of (−)-Epigallocatechin Gallate: Participation of Reversible Covalent Binding for Interaction and Stabilization

ISHII, Takeshi, ICHIKAWA, Tatsuya, MINODA, Kanako, KUSAKA, Koji, ITO, Sohei, SUZUKI, Yukiko, AKAGAWA, Mitsugu, MOCHIZUKI, Kazuki, GODA, Toshinao, NAKAYAMA, Tsutomu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2011

Language:

english

File:

PDF, 318 KB

english, 2011

32

Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation–Modification of Proteins in Vitro : Identification of N τ -(3-Propanal)histidine as the Major Adduct

Maeshima, Takuya, Honda, Kazuya, Chikazawa, Miho, Shibata, Takahiro, Kawai, Yoshichika, Akagawa, Mitsugu, Uchida, Koji

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 715 KB

english, 2012

33

Metal-Catalyzed Oxidation of Protein-Bound Dopamine †

Akagawa, Mitsugu, Ishii, Yoshihisa, Ishii, Takeshi, Shibata, Takahiro, Yotsu-Yamashita, Mari, Suyama, Kyozo, Uchida, Koji

Journal:

Year:

2006

Language:

english

File:

PDF, 449 KB

english, 2006

34

Oxidative Deamination of Benzylamine and Lysine Residue in Bovine Serum Albumin by Green Tea, Black Tea, and Coffee

Akagawa, Mitsugu, Shigemitsu, Tomoko, Suyama, Kyozo

Journal:

Journal of Agricultural and Food Chemistry

Year:

2005

Language:

english

File:

PDF, 191 KB

english, 2005

35

An acyl-SAM analog as an affinity ligand for identifying quorum sensing signal synthases

Kai, Kenji, Fujii, Hiroki, Ikenaka, Rui, Akagawa, Mitsugu, Hayashi, Hideo

Journal:

Chemical Communications

Year:

2014

Language:

english

File:

PDF, 1.37 MB

english, 2014

36

Oxidative Deamination by Hydrogen Peroxide in the Presence of Metals

Akagawa, Mitsugu, Suyama, Kyozo

Journal:

Free Radical Research

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

37

α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts

Tsuji-Naito, Kentaro, Ishikura, Seiko, Akagawa, Mitsugu, Saeki, Hiroshi

Journal:

Connective Tissue Research

Year:

2010

Language:

english

File:

PDF, 511 KB

english, 2010

38

Mechanism of Formation of Elastin Crosslinks

Akagawa, Mitsugu, Suyama, Kyozo

Journal:

Connective Tissue Research

Year:

2000

Language:

english

File:

PDF, 705 KB

english, 2000

39

Assessment of Prion Inactivation by Fenton Reaction Using Protein Misfolding Cyclic Amplification and Bioassay

SUYAMA, Kyozo, YOSHIOKA, Miyako, AKAGAWA, Mitsugu, MURAYAMA, Yuichi, HORII, Hiroko, TAKATA, Masuhiro, YOKOYAMA, Takashi, MOHRI, Shirou

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

40

Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

Ishii, Megumi, Maeda, Ayumi, Tani, Shuji, Akagawa, Mitsugu

Journal:

Archives of Biochemistry and Biophysics

Year:

2015

Language:

english

File:

PDF, 2.08 MB

english, 2015

41

Covalent Binding of Tea Catechins to Protein Thiols: The Relationship between Stability and Electrophilic Reactivity

MORI, Taiki, ISHII, Takeshi, AKAGAWA, Mitsugu, NAKAMURA, Yoshimasa, NAKAYAMA, Tsutomu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

42

Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications

ISHII, Takeshi, AKAGAWA, Mitsugu, NAITO, Yuji, HANDA, Osamu, TAKAGI, Tomohisa, MORI, Taiki, KUMAZAWA, Shigenori, YOSHIKAWA, Toshikazu, NAKAYAMA, Tsutomu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2010

Language:

english

File:

PDF, 410 KB

english, 2010

43

β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes

Kamikubo, Ryosuke, Kai, Kenji, Tsuji-Naito, Kentaro, Akagawa, Mitsugu

Journal:

Molecular Nutrition & Food Research

Year:

2016

Language:

english

File:

PDF, 2.37 MB

english, 2016

44

H+/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport

Kudo, Michiko, Katayoshi, Takeshi, Kobayashi-Nakamura, Kumiko, Akagawa, Mitsugu, Tsuji-Naito, Kentaro

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1.36 MB

english, 2016

45

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein

Akagawa, Mitsugu, Minematsu, Kenji, Shibata, Takahiro, Kondo, Tatsuhiko, Ishii, Takeshi, Uchida, Koji

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.07 MB

english, 2016

46

Pyridoxamine scavenges protein carbonyls and inhibits protein aggregation in oxidative stress-induced human HepG2 hepatocytes

Dainin, Kohei, Ide, Ryoko, Maeda, Ayumi, Suyama, Kyozo, Akagawa, Mitsugu

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 1.30 MB

english, 2017

47

Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives

Imanishi, Mia, Sonoda, Motohiro, Miyazato, Hironari, Sugimoto, Keiichiro, Akagawa, Mitsugu, Tanimori, Shinji

Journal:

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

48

Identification of polyphenol-specific innate epitopes originated from a resveratrol analogue

Furuhashi, Mai, Hatasa, Yukinori, Kawamura, Sae, Shibata, Takahiro, Akagawa, Mitsugu, Uchida, Koji

Journal:

Year:

2017

Language:

english

File:

PDF, 23.19 MB

english, 2017

49

Piperine Promotes Glucose Uptake Through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle

Maeda, Ayumi, Shirao, Takeshi, Shirasaya, Daishi, Yoshioka, Yasukiyo, Yamashita, Yoko, Akagawa, Mitsugu, Ashida, Hitoshi

Journal:

Molecular Nutrition & Food Research

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

50

10.1271/kagakutoseibutsu1962.40.112

AKAGAWA, MITSUGU

Journal:

KAGAKU TO SEIBUTSU

Year:

2002

File:

PDF, 248 KB

2002

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